![US-Photofix-Hero-1130x942 US-Photofix-Hero-1130x942](https://artivion.com/wp-content/uploads/2023/02/US-Photofix-Hero-1130x942-1.png)
PhotoFix®
DECELLULARIZED BOVINE PERICARDIUM
Feel the Difference.
![US-Photofix-2-Product-Highlights-1272x954](https://artivion.com/wp-content/uploads/2023/02/US-Photofix-2-Product-Highlights-1272x954-1.png)
Product Highlights
- No aldehyde chemistry used in any part of the process.1
- Nonimmunogenic, biocompatible, non-cytotoxic, and maintains natural physical properties and biomechanical integrity.2
- Feels similar to autologous tissue, and is easy to trim, shape, and suture.1
Product Overview
1. NO ALDEHYDE CHEMISTRY
PhotoFix uses dye-mediated photo-oxidization to crosslink and stabilize the internal collagen structure – eliminating toxic by-products that create sites where calcium can bind to tissue.1-4
2. FEEL THE DIFFERENCE
Feels similar to Autologous tissue and is easy to trim and shape.
![US-Photofix-Callout-1-Column-2](https://artivion.com/wp-content/uploads/2023/02/US-Photofix-Callout-1-Column-2.png)
3. RELIABLE STRENGTH
Strong, uniform, and easy to suture.
![US-Photofix-Callout-1-Column-3](https://artivion.com/wp-content/uploads/2023/02/US-Photofix-Callout-1-Column-3.png)
4. READY TO USE
NO Rinsing, NO Rehydrating, and
NO Waiting.
![US-Photofix-Callout-1-Column-4](https://artivion.com/wp-content/uploads/2023/02/US-Photofix-Callout-1-Column-4.png)
![US-Photofix-Design-Features-2554x1200](https://artivion.com/wp-content/uploads/2023/02/US-Photofix-Design-Features-2554x1200-1.png)
Clinical Evidence
USE OF PHOTOFIX IN CONGENITAL CARDIAC SURGERY AT BOSTON CHILDREN'S HOSPITAL1
- 490 patches used between 2008 and 2011 in 364 patients (median age 5.3 years).
- Mean late follow-up of 3.2±1.6 years.
- Demonstrated excellent performance in cardiovascular repair in children.
- Wide range of applications show consistent handling characteristics and biocompatibility.
- Eight patch specimens were available for histological analysis (up to 72 months):
- “Inflammation was absent or minimal in 6 cases and mild in 2 others.”1
- “No calcification noted in 5 cases, mild calcification in 2 cases and at least moderate calcification in 1 case.”1
![PhotoFix-Clinical-1 copy](https://artivion.com/wp-content/uploads/2023/03/PhotoFix-Clinical-1-copy.jpg)
ANIMAL STUDIES HAVE SHOWN:
- There was no evidence of collagen degradation, thrombogenicity, infection, excessive inflammation or intrinsic calcification in sheep animal models (140 days).2
- PhotoFix process has demonstrated no significant calcification in both subcutaneous rat (60 days) implants and juvenile sheep (140 days) animal models.2
- Endothelial cell growth is supported in vitro by photooxidized pericardium and vascular grafts (Figure 3).3
![PhotoFix-Clinical-2-2 copy](https://artivion.com/wp-content/uploads/2023/03/PhotoFix-Clinical-2-2-copy.jpg)
STRUCTURAL STRENGTH:
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Comparison of biomechanical performance patches.
![PhotoFix Clinical 3](https://artivion.com/wp-content/uploads/2021/12/PhotoFix-Clinical-3.png)
Additional Resources
Explore additional resources for PhotoFix below. For further information or to contact a sales associate in your area, contact us.
Product Highlights
- Artivion, Inc. Data on file.
- Schmidt C E, et. al. (2000). Acellular vascular tissues: Natural biomaterials for tissue repair and tissue engineering. Biomaterials, 21(22), 2215-2231.
Product Overview
- Schoen, F J, et. al. (2005). Calcification of tissue heart valve substitutes: progress toward understanding and prevention. Ann Thorac Surg, 79(3), 1072-1080.
- Umashankar P R, et. al. (2012). Glutaraldehyde treatment elicits toxic response compared to decellularization in bovine pericardium. Toxicol Int, 19(1), 51-58.
- Golomb G, et. al. (1987). The role of glutaraldehyde-induced cross-links in calcification of bovine pericardium used in cardiac valve bioprostheses. Am J Pathol, 127(1), 122-130.
- Moore M A, et. al. (2001). Calcification resistance, biostability, and low immunogenic potential of porcine heart valves modified by dye-mediated photooxidation. J Biomed Mater Res, 56(1), 24-30.
Clinical Evidence
- Baird C, et. al. (2016). Photo-oxidized bovine pericardium in congenital cardiac surgery: single-centre experience. Interact Cardiovasc Thorac Surg, 24(2), 240-244.
- Artivion, Inc. Pre-Clinical Data on File.
- Schmidt C E, et. al. (2000). Acellular vascular tissues: Natural biomaterials for tissue repair and tissue engineering. Biomaterials, 21(22), 2215-2231.
- Artivion, Inc. Data on file.
All products and indications are not available/approved in all markets. All trademarks are owned by Artivion, Inc. or its subsidiaries. On-X Life Technologies, Inc., Jotec GmbH, and Ascyrus Medical GmbH are wholly owned subsidiaries of Artivion, Inc. MLENG1605.002 (2023-10)
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Artivion, Inc., 1655 Roberts Blvd NW, Kennesaw, GA 30144, US |