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On-X®

ASCENDING AORTIC PROSTHESIS

The Most Advanced Aortic Valved Conduit.

On-X AAP - Product Highlight

Product Highlights

  • The most advanced aortic valved conduit combining the On-X Aortic Valve and Vascutek® Gelweave® Valsalva™ Graft.
  • Valsalva Graft geometry mimics the sinus of Valsalva and is designed for optimal coronary ostia reimplantation.1
  • On-X Aortic Valve with Conform-X Sewing Ring provides optimal hemodynamics with ease of suturing.2

Product Overview

Design Features Accessories
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1. 90° LEAFLET OPENING

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On-X Aortic Valves

90° leaflet opening organizes flow1, reducing turbulence and thrombogenicity.3
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All Other Bileaflet Valves

< 90º leaflet opening can lead to turbulent flow3

2. PURE PYROLYTIC CARBON

Designed to reduce thrombogenicity1-2

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On-X Heart Valves

Pure Pyrolytic Carbon2
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All Other Bileaflet Valves

Silicone-Alloyed Pyrolytic Carbon2

3. COMPLETE ANNULUS SUPPORT

Flared inlet organizes flow & prevents pannus1

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On-X Heart Valves

Complete Annulus Support
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All Other Bileaflet Valves

Incomplete Annulus Support

4. VALSALVA GRAFT

Mimics the geometry of the sinus of Valsalva1

5. CONFORM-X PTFE SEWING RING

For ease of suturing

AAP Features
On-X Call Out

CYLINDRICAL END

For aortic valve sizes 19-25mm, the cylindrical end is used to find the correct fit.

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REPLICA END

For aortic valve sizes 19-25mm, the replica end is used after sizing to ensure the fit of the valve without the obstruction of the coronary arteries

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Conical End Size

For aortic valve sizes 27/29mm and 31/33mm, the conical end sizer is used to find the correct fit and assure intra-annular positioning. 

In comparison to the On-X AAP, no non-native aortic valve has been able to produce 3D, in vivo hemodynamics that so closely approach flow patterns observed in healthy volunteers.

Dr. S. Chris Malaisrie, United States

Clinical Evidence

Exceptional Laminar Flow

Aortic root replacement (ARR) with the On-X Ascending Aortic Prosthesis demonstrates significantly reduced aberrant ascending aortic hemodynamics in comparison to other mechanical valved conduits.1

 

  • Four-dimensional (4D) flow magnetic resonance imaging (MRI) and transthoracic echocardiography (TTE) substantiate that ARR with the On-X Ascending Aortic Prosthesis creates a less turbulent blood flow, producing flow patterns that resemble those in healthy volunteers.1

 

Click here to read the publication.

On-X AAP Clinical Chart

Product Video

On-X Ascending Aortic Prosthesis 4D Flow Imaging Video

The On-X Ascending Aortic Prosthesis significantly reduces abnormal ascending aortic hemodynamics when compared to flow patterns for alternative valve designs.1-2

Additional Resources

Explore additional resources for On-X AAP below. For further information or to contact a sales associate in your area, contact us.

Ordering Information

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MRI Information

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Patient Information Site

VISIT PATIENT SITE

Product Highlights

  1. On-X Ascending Aortic Prosthesis Instructions for Use (01012498B)
  2. Keller EJ, et. al. (2016). Reduction of aberrant aortic haemodynamics following aortic root replacement with a mechanical valved conduit. Interact CardioVasc Thorac Surg, 23(3), 416-23. doi: 10.1093/icvts/ivw173.

 

Product Overview

  1. On-X Ascending Aortic Prosthesis Instructions for Use (01012498B).
  2. LaGrange L, et. al. (1969, June 9-13). Compatibility of carbon and blood. Artificial Heart Program Conference, Washington, DC.
  3. Gerdisch M. et al. (2022) The role of mechanical valves in the aortic position in the era of bioprostheses and TAVR: Evidence-based appraisal and focus on the On-X valve. Prog Cardiovasc Dis. 72:31-40. doi: 10.1016/j.pcad.2022.06.001. 

Product Video

  1. Keller EJ, et. al. (2016). Reduction of aberrant aortic haemodynamics following aortic root replacement with a mechanical valved conduit. Interact CardioVasc Thorac Surg, 23(3), 416-23. doi: 10.1093/icvts/ivw173.
  2. von Knobelsdorff-Brenkenhoff F, et. al. (2014). Blood flow characteristics in the ascending aorta after aortic valve replacement – a pilot study using 4D-flow MRI. Int J Cardiol, 170(3), 426-33.

Clinical Evidence

  1. Keller EJ, et. al. (2016). Reduction of aberrant aortic haemodynamics following aortic root replacement with a mechanical valved conduit. Interact CardioVasc Thorac Surg, 23(3), 416-23. doi: 10.1093/icvts/ivw173.

All products and indications are not available/approved in all markets. All trademarks are owned by Artivion, Inc. or its subsidiaries. On-X Life Technologies, Inc., Jotec GmbH, and Ascyrus Medical GmbH are wholly owned subsidiaries of Artivion, Inc. MLENG1604.000. (2023-04)

On-X Life Technologies, 1300 E Anderson Ln, Austin, TX 78752, US